A model of the unfolded protein response: pancreatic beta-cell as a case study.

Abstract excerpt

Pancreatic beta-cell failure is increasingly recognized as central to the progression of diabetes mellitus. Different causes are implicated in the onset of beta-cell stress, dysfunction or death. Recent genetic and biochemical evidence both in humans and mice shows that failure in modulating the capacity and quality of the endoplasmic reticulum protein-folding machinery leads to beta-cell death. The quality...

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