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Article

Effects of the loss of conjunctival Muc16 on corneal epithelium and stroma in mice.

Investigative ophthalmology & visual science - 8 May 2014

Shirai Kumi, Okada Yuka, Cheon Dong-Joo, Miyajima Masayasu, Behringer Richard R, Yamanaka Osamu, Saika Shizuya

Abstract excerpt

PURPOSE: To examine the role of conjunctival Muc16 in the homeostasis of the ocular surface epithelium and stroma using Muc16-null knockout (KO) mice. METHODS: We used KO mice (n = 58) and C57/BL6 (WT) mice (n = 58). Histology and immunohistochemistry were employed to analyze the phenotypes in the ocular surface epithelium. The expression of phospho-Stat3, AP-1 components, interleukin 6 (IL-6), and tumor necrosis...

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Source

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Identifiers

PMID: 24812549
DOI: 10.1167/iovs.13-12955
PMCID: PMC4581617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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