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Article

Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease.

PloS one - 1 Jan 2013

Chen Ying Ting, Chen Feeling Y T, Vijmasi Trinka, Stephens Denise N, Gallup Marianne, McNamara Nancy A

Abstract excerpt

Keratinizing squamous metaplasia (SQM) of the ocular surface is a blinding consequence of systemic autoimmune disease and there is no cure. Ocular SQM is traditionally viewed as an adaptive tissue response during chronic keratoconjunctivitis sicca (KCS) that provokes pathological keratinization of the corneal epithelium and fibrosis of the corneal stroma. Recently, we established the autoimmune regulator-knockout...

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Identifiers

PMID: 24143217
DOI: 10.1371/journal.pone.0077286
PMCID: PMC3797128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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