Article

Keratin 6a attenuates Toll-like receptor-triggered proinflammatory response in corneal epithelial cells by suppressing ELKS/IKKε-dependent activation of NF-κB

2023-10-27

Abstract excerpt

The corneal epithelium at the ocular surface is constantly exposed to the environment and represents the first line of defense against infection, mechanical injury or chemical irritation. Through TLR-mediated recognition of pathogen- and damage-associated molecular patterns, it engages in direct antimicrobial responses and alerts the immune system on intruder and tissue damage by secreting pro-inflammatory and che...

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Identifiers and source

Literature Corpus work: 8ab6738a-b2b8-5263-858f-b19fd3dc1352
DOI: 10.1101/2023.10.24.563888

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