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Article

Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.

Development (Cambridge, England) - 1 Feb 2013

Zhang Yujin, Lam Oliver, Nguyen Minh-Thanh T, Ng Gracia, Pear Warren S, Ai Walden, Wang I-Jong, Kao Winston W-Y, Liu Chia-Yang

Abstract excerpt

Conjunctival goblet cells primarily synthesize mucins to lubricate the ocular surface, which is essential for normal vision. Notch signaling has been known to associate with goblet cell differentiation in intestinal and respiratory tracts, but its function in ocular surface has yet to be fully characterized. Herein, we demonstrate that conditional inhibition of canonical Notch signaling by expressing dominant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23293291
DOI: 10.1242/dev.082842
PMCID: PMC3561782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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