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Article

MUC1/A and MUC1/B splice variants differentially regulate inflammatory cytokine expression.

Experimental eye research - 1 Nov 2011

Imbert-Fernandez Yoannis, Radde Brandie N, Teng Yun, Young William W, Hu Chuan, Klinge Carolyn M

Abstract excerpt

The frequency of a splice variant of mucin 1 (MUC1), MUC1/A was lower in dry eye disease patients compared to normal controls, suggesting a link between the absence of MUC1/A and the development of dry eye disease which is characterized by chronic inflammation. The objectives of the present study were to clone and characterize the phenotype of cells expressing solely MUC1/A versus MUC1/B or a variant lacking the...

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Identifiers

PMID: 21854773
DOI: 10.1016/j.exer.2011.08.004
PMCID: PMC3221811

Genes

MUC1

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