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Article

Mucin deficiency causes functional and structural changes of the ocular surface.

PloS one - 1 Jan 2012

Floyd Anne M, Zhou Xu, Evans Christopher, Rompala Olivia J, Zhu Lingxiang, Wang Mingwu, Chen Yin

Abstract excerpt

MUC5AC is the most abundant gel-forming mucin in the ocular system. However, the specific function is unknown. In the present study, a Muc5ac knockout (KO) mouse model was subject to various physiological measurements as compared to its wide-type (WT) control. Interestingly, when KO mice were compared to WT mice, the mean tear break up time (TBUT) values were significantly lower and corneal fluorescein staining...

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Source

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Identifiers

PMID: 23272068
DOI: 10.1371/journal.pone.0050704
PMCID: PMC3525643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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