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MUC16: molecular analysis and its functional implications in benign and malignant conditions

2 Jul 2014

Abstract excerpt

MUC16 is a high-molecular-weight glycoprotein that is expressed by the various epithelial cell surfaces of the human body to protect the cell layer from a myriad of insults. It is the largest mucin known to date, with an ∼22,152 aa sequence. Structurally, MUC16 is characterized into 3 distinct domains: the amino terminal, the tandem repeat, and the carboxyl terminal domain, with each domain having unique...

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PMID: 25002120
DOI: 10.1096/fj.14-257352

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