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Article

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.

Science (New York, N.Y.) - 9 May 2014

Tran Eric, Turcotte Simon, Gros Alena, Robbins Paul F, Lu Yong-Chen, Dudley Mark E, Wunderlich John R, Somerville Robert P, Hogan Katherine, Hinrichs Christian S, Parkhurst Maria R, Yang James C, Rosenberg Steven A

Abstract excerpt

Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with metastatic cholangiocarcinoma contained CD4+ T helper 1 (T(H)1) cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts, Intrahepatic

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Source

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Identifiers

PMID: 24812403
DOI: 10.1126/science.1251102
PMCID: PMC6686185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24812403-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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