Article
Immunogenicity of somatic mutations in human gastrointestinal cancers.
Science (New York, N.Y.) - 11 Dec 2015
Tran Eric, Ahmadzadeh Mojgan, Lu Yong-Chen, Gros Alena, Turcotte Simon, Robbins Paul F, Gartner Jared J, Zheng Zhili, Li Yong F, Ray Satyajit, Wunderlich John R, Somerville Robert P, Rosenberg Steven A
Abstract excerpt
It is unknown whether the human immune system frequently mounts a T cell response against mutations expressed by common epithelial cancers. Using a next-generation sequencing approach combined with high-throughput immunologic screening, we demonstrated that tumor-infiltrating lymphocytes (TILs) from 9 out of 10 patients with metastatic gastrointestinal cancers contained CD4(+) and/or CD8(+) T cells that...
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