Article
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer.
Nature medicine - 1 Jun 2018
Zacharakis Nikolaos, Chinnasamy Harshini, Black Mary, Xu Hui, Lu Yong-Chen, Zheng Zhili, Pasetto Anna, Langhan Michelle, Shelton Thomas, Prickett Todd, Gartner Jared, Jia Li, Trebska-McGowan Katarzyna, Somerville Robert P, Robbins Paul F, Rosenberg Steven A, Goff Stephanie L, Feldman Steven A
Abstract excerpt
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations-such as melanoma, smoking-induced lung cancers and bladder cancer-with little effect in other common epithelial cancers that have lower mutation rates, such as those arising in the gastrointestinal tract, breast and ovary1-7. Adoptive...
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