Article
Discovery and Subtyping of Neo-Epitope Specific T-Cell Responses for Cancer Immunotherapy: Addressing the Mutanome.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Diken Mustafa, Vormehr Mathias, Grunwitz Christian, Kreiter Sebastian, Türeci Özlem, Sahin Ugur
Abstract excerpt
Cancer accumulates 10s to 1000s of genomic mutations of which a fraction is immunogenic and may serve as an Achilles' heel of tumor cells. Mutation-specific T cells can recognize these antigens and destroy malignant cells. Strategies to immunotherapeutically address individual tumor mutations employing peptide or mRNA based vaccines are now actively investigated in mice and humans. An important step of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.