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Article

Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

Oncotarget - 15 May 2014

Lopez-Delisle Lucille, Pierre-Eugène Cécile, Bloch-Gallego Evelyne, Birling Marie-Christine, Duband Jean-Loup, Durand Estelle, Bourgeois Thomas, Matrot Boris, Sorg Tania, Huerre Michel, Meziane Hamid, Roux Michel J, Champy Marie-France, Gallego Jorge, Delattre Olivier, Janoueix-Lerosey Isabelle

Abstract excerpt

The ALK (Anaplastic Lymphoma Kinase) gene encodes a tyrosine kinase receptor preferentially expressed in the central and peripheral nervous systems. A syndromic presentation associating congenital neuroblastoma with severe encephalopathy and an abnormal shape of the brainstem has been described in patients harbouring de novo germline F1174V and F1245V ALK mutations. Here, we investigated the phenotype of knock-in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24811761
DOI: 10.18632/oncotarget.1882
PMCID: PMC4058038

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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