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Article

Role of the parental NF1 carrier in effects of pharmacological inhibition of anaplastic lymphoma kinase in Neurofibromatosis 1 mutant mice.

Brain research - 15 Oct 2021

Krenik Destine, Weiss Joseph B, Raber Jacob

Abstract excerpt

Neurofibromatosis type 1 (NF1), a genetically determined neurodevelopmental disorder and tumor syndrome, is associated with cognitive impairments, including in executive function and sleep-related problems. Consistent with the human data, NF1 heterozygous (Het) mice show impaired spatial learning and memory in the water maze and extinction of contextual fear memory. It is not clear whether neurological phenotypes...

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PMID: 34339711
DOI: 10.1016/j.brainres.2021.147594

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