Article
KIT is required for hepatic function during mouse post-natal development.
BMC developmental biology - 5 Jul 2007
Magnol Laetitia, Chevallier Marie-Clémence, Nalesso Valérie, Retif Stéphanie, Fuchs Helmut, Klempt Martina, Pereira Patricia, Riottot Michel, Andrzejewski Sandra, Doan Bich-Thuy, Panthier Jean-Jacques, Puech Anne, Beloeil Jean-Claude, de Angelis Martin Hrabe, Hérault Yann
Abstract excerpt
BACKGROUND: The Kit gene encodes a receptor tyrosine kinase involved in various biological processes including melanogenesis, hematopoiesis and gametogenesis in mice and human. A large number of Kit mutants has been described so far showing the pleiotropic phenotypes associated with partial loss-of-function of the gene. Hypomorphic mutations can induce a light coat color phenotype while complete lack of KIT...
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