Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells

8 May 2014

Abstract excerpt

The Hedgehog-GLI signaling pathway is active in a variety of human malignancies and is known to contribute to the growth and survival of human osteosarcoma cells. In this study, we examined the expression and regulation of GLI transcription factors in multiple canine osteosarcoma cell lines and analyzed the effects of inhibiting GLI with GANT61, a GLI-specific inhibitor. Compared with normal canine osteoblasts,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Ear and Nasal Anomalies
Share to Genomics and Chromatin Dynamics
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24810746
DOI: 10.1371/journal.pone.0096593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma CellsPMID 24810746Read ↗

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceSemantic proximity Read ↗

Global Gene Expression Analysis of Canine Osteosarcoma Stem Cells Reveals a Novel Role for COX-2 in Tumour InitiationSemantic proximity Read ↗

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.Semantic proximity Read ↗

Reduction of Human Embryonal Rhabdomyosarcoma Tumor Growth by Inhibition of the Hedgehog Signaling PathwaySemantic proximity Read ↗

HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumorsSemantic proximity Read ↗

Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growthSemantic proximity Read ↗

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.Semantic proximity Read ↗

Characterization of STAT3 activation and expression in canine and human osteosarcomaSemantic proximity Read ↗

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA bindingSemantic proximity Read ↗

GANT‐61 and GDC‐0449 induce apoptosis of prostate cancer stem cells through a GLI‐dependent mechanismSemantic proximity Read ↗

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.