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Article

Characterization of STAT3 activation and expression in canine and human osteosarcoma

10 Mar 2009

Abstract excerpt

BACKGROUND: Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more malignant tumor phenotype. STAT3 phosphorylation has been demonstrated in a subset of human osteosarcoma (OSA) tissues and cell lines. OSA in the canine population is known to exhibit a similar...

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PMID: 19284568
DOI: 10.1186/1471-2407-9-81

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