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Article

Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth

14 Jun 2011

Abstract excerpt

The Hedgehog pathway functions as an organizer in embryonic development. Recent studies have shown that mutation of the PTCH1 gene involved in the Hedgehog pathway affects rhabdomyosarcoma development. However, the expression of Hedgehog pathway molecules in human rhabdomyosarcoma cells has not been well clarified. In addition, the effect of pharmacological inhibition of the Hedgehog pathway is not known. We...

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PMID: 21674124
DOI: 10.3892/ijo.2011.1076

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