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HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors

1 Jul 2013

Abstract excerpt

BACKGROUND: Hairy and enhancer of split 1 (HES1), a basic helix-loop-helix transcriptional repressor, is a downstream target of Notch signaling. Notch signaling and HES1 expression have been linked to growth and survival in a variety of human cancer types and have been associated with increased metastasis and invasiveness in human osteosarcoma cell lines. Osteosarcoma (OSA) is an aggressive cancer demonstrating...

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PMID: 23816051
DOI: 10.1186/1746-6148-9-130

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