Article
MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.
BMC cancer - 10 Oct 2016
Fenger Joelle M, Roberts Ryan D, Iwenofu O Hans, Bear Misty D, Zhang Xiaoli, Couto Jason I, Modiano Jaime F, Kisseberth William C, London Cheryl A
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) regulate the expression of networks of genes and their dysregulation is well documented in human malignancies; however, limited information exists regarding the impact of miRNAs on the development and progression of osteosarcoma (OS). Canine OS exhibits clinical and molecular features that closely resemble the corresponding human disease and it is considered a well-established...
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