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Article

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth <i>in vitro</i> and <i>in vivo</i>

5 Sept 2012

Abstract excerpt

Hedgehog (HH) signaling is an important regulator of embryogenesis that has been associated with the development of several types of cancer. HH signaling is characterized by Smoothened (SMO)-dependent activation of the GLI transcription factors, which regulate the expression of critical developmental genes. Neuroblastoma, an embryonal tumor of the sympathetic nervous system, was recently shown to express high...

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PMID: 22949014
DOI: 10.1002/ijc.27820

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