Article
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nature communications - 8 May 2014
Liu Jinfeng, McCleland Mark, Stawiski Eric W, Gnad Florian, Mayba Oleg, Haverty Peter M, Durinck Steffen, Chen Ying-Jiun, Klijn Christiaan, Jhunjhunwala Suchit, Lawrence Michael, Liu Hanbin, Wan Yinan, Chopra Vivek, Yaylaoglu Murat B, Yuan Wenlin, Ha Connie, Gilbert Houston N, Reeder Jens, Pau Gregoire, Stinson Jeremy, Stern Howard M, Manning Gerard, Wu Thomas D, Neve Richard M, de Sauvage Frederic J, Modrusan Zora, Seshagiri Somasekar, Firestein Ron, Zhang Zemin
Abstract excerpt
Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we perform exome and transcriptome sequencing and SNP array assays to characterize 51 primary gastric tumours and 32 cell lines. Meta-analysis of exome data and previously published data sets reveals 24 significantly mutated genes in microsatellite stable (MSS) tumours...
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