Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.

doi:10.1038/nm.3850

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Article

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.

Nature medicine - 1 May 2015

Cristescu Razvan, Lee Jeeyun, Nebozhyn Michael, Kim Kyoung-Mee, Ting Jason C, Wong Swee Seong, Liu Jiangang, Yue Yong Gang, Wang Jian, Yu Kun, Ye Xiang S, Do In-Gu, Liu Shawn, Gong Lara, Fu Jake, Jin Jason Gang, Choi Min Gew, Sohn Tae Sung, Lee Joon Ho, Bae Jae Moon, Kim Seung Tae, Park Se Hoon, Sohn Insuk, Jung Sin-Ho, Tan Patrick, Chen Ronghua, Hardwick James, Kang Won Ki, Ayers Mark, Hongyue Dai, Reinhard Christoph, Loboda Andrey, Kim Sung, Aggarwal Amit

Abstract excerpt

Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would encompass this heterogeneity and provide useful clinical information. We use gene expression data to describe four molecular subtypes linked to distinct patterns of molecular alterations, disease progression and prognosis. The mesenchymal-like type includes...

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PMID: 25894828
DOI: 10.1038/nm.3850

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