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Article

Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

Cancer research - 1 Jan 2011

Zang Zhi Jiang, Ong Choon Kiat, Cutcutache Ioana, Yu Willie, Zhang Shen Li, Huang Dachuan, Ler Lian Dee, Dykema Karl, Gan Anna, Tao Jiong, Lim Siyu, Liu Yujing, Futreal P Andrew, Grabsch Heike, Furge Kyle A, Goh Liang Kee, Rozen Steve, Teh Bin Tean, Tan Patrick

Abstract excerpt

Genetic alterations in kinases have been linked to multiple human pathologies. To explore the landscape of kinase genetic variation in gastric cancer (GC), we used targeted, paired-end deep sequencing to analyze 532 protein and phosphoinositide kinases in 14 GC cell lines. We identified 10,604 si...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21097718
DOI: 10.1158/0008-5472.CAN-10-1749
PMCID: PMC3719377

Genes

MET
CDK12
CDKL5
ERBB2
FER
STK31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21097718-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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