Article
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer.
Nature genetics - 30 Oct 2011
Wang Kai, Kan Junsuo, Yuen Siu Tsan, Shi Stephanie T, Chu Kent Man, Law Simon, Chan Tsun Leung, Kan Zhengyan, Chan Annie S Y, Tsui Wai Yin, Lee Siu Po, Ho Siu Lun, Chan Anthony K W, Cheng Grace H W, Roberts Peter C, Rejto Paul A, Gibson Neil W, Pocalyko David J, Mao Mao, Xu Jiangchun, Leung Suet Yi
Abstract excerpt
Gastric cancer is a heterogeneous disease with multiple environmental etiologies and alternative pathways of carcinogenesis. Beyond mutations in TP53, alterations in other genes or pathways account for only small subsets of the disease. We performed exome sequencing of 22 gastric cancer samples and identified previously unreported mutated genes and pathway alterations; in particular, we found genes involved in...
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