Article
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.
Gut - 1 May 2012
Deng Niantao, Goh Liang Kee, Wang Hannah, Das Kakoli, Tao Jiong, Tan Iain Beehuat, Zhang Shenli, Lee Minghui, Wu Jeanie, Lim Kiat Hon, Lei Zhengdeng, Goh Glenn, Lim Qing-Yan, Tan Angie Lay-Keng, Sin Poh Dianne Yu, Riahi Sudep, Bell Sandra, Shi Michael M, Linnartz Ronald, Zhu Feng, Yeoh Khay Guan, Toh Han Chong, Yong Wei Peng, Cheong Hyun Cheol, Rha Sun Young, Boussioutas Alex, Grabsch Heike, Rozen Steve, Tan Patrick
Abstract excerpt
OBJECTIVE: Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of exclusivity and co-occurrence among these targets, through comprehensive genomic analysis of a large panel of gastric cancers. DESIGN: Using high-resolution...
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