Article
MC1R Functions, Expression, and Implications for Targeted Therapy.
The Journal of investigative dermatology - 1 Feb 2022
Guida Stefania, Guida Gabriella, Goding Colin Ronald
Abstract excerpt
The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition. Beyond its role in pigmentation, MC1R is increasingly recognized as promoting UV-induced DNA damage repair. Consequently, there is mounting interest in targeting MC1R for therapeutic benefit....
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