Article
Association of TERT promoter mutation 1,295,228 C>T with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer.
The Journal of clinical endocrinology and metabolism - 1 Apr 2015
Shi Xiaoguang, Liu Rengyun, Qu Shen, Zhu Guangwu, Bishop Justin, Liu Xiaoli, Sun Hui, Shan Zhongyan, Wang Enhua, Luo Yahong, Yang Xianghong, Zhao Jiajun, Du Jianling, El-Naggar Adel K, Teng Weiping, Xing Mingzhao
Abstract excerpt
CONTEXT: The aggressive role of TERT promoter mutations has been well established in differentiated thyroid cancer but has not been established in anaplastic thyroid cancer (ATC). RESEARCH DESIGN: We tested the mutation status by sequencing genomic tumor DNA and examined its relationship with clinicopathological characteristics of ATC. RESULTS: Among 106 American and Chinese ATC samples, TERT 1,295,228 C>T...
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