Article
Highly prevalent TERT promoter mutations in aggressive thyroid cancers.
Endocrine-related cancer - 1 Aug 2013
Liu Xiaoli, Bishop Justin, Shan Yuan, Pai Sara, Liu Dingxie, Murugan Avaniyapuram Kannan, Sun Hui, El-Naggar Adel K, Xing Mingzhao
Abstract excerpt
Mutations 1 295 228 C>T and 1 295 250 C>T (termed C228T and C250T respectively), corresponding to -124 C>T and -146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, have recently been reported in human cancers, but not in thyroid cancers yet. We explored these mutations in thyroid cancers by genomic sequencing of a large number of primary tumor samples. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.