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Article

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

Genes, brain, and behavior - 1 Oct 2010

Middeldorp C M, Slof-Op 't Landt M C T, Medland S E, van Beijsterveldt C E M, Bartels M, Willemsen G, Hottenga J-J, de Geus E J C, Suchiman H E D, Dolan C V, Neale M C, Slagboom P E, Boomsma D I

Abstract excerpt

There are two major hypotheses regarding the etiology of anxiety and depression: the mono-amine hypothesis and the hypothesis of an abnormal stress response acting partly via reduced neurogenesis. Association studies have focused on genes involved in these processes, but with inconclusive results. This study investigated the effect of 45 single nucleotide polymorphisms (SNPs) in genes encoding for serotonin...

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Identifiers

PMID: 20633049
DOI: 10.1111/j.1601-183X.2010.00619.x
PMCID: PMC3151552

Genes

BDNF
COMT
TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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