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Article

Reduced blood pressure of CFTR-F508del carriers correlates with diminished arterial reactivity rather than circulating blood volume in mice.

PloS one - 1 Jan 2014

Peotta Veronica A, Bhandary Prasad, Ogu Ugochi, Volk Kenneth A, Roghair Robert D

Abstract excerpt

The F508del mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis (CF). Both CF patients and F508del carriers have decreased blood pressure. While this has been attributed to salt depletion, recent studies have shown F508del expression interferes with smooth muscle cell calcium mobilization. We tested the hypothesis that carriers of the F508del...

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Source

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Identifiers

PMID: 24801204
DOI: 10.1371/journal.pone.0096756
PMCID: PMC4011854

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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