Article
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter.
American journal of physiology. Heart and circulatory physiology - 1 Nov 2002
Meyer Jamie W, Flagella Michael, Sutliff Roy L, Lorenz John N, Nieman Michelle L, Weber Craig S, Paul Richard J, Shull Gary E
Abstract excerpt
The basolateral Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) functions in the maintenance of cellular electrolyte and volume homeostasis. NKCC1-deficient (Nkcc1(-/-)) mice were used to examine its role in cardiac function and in the maintenance of blood pressure and vascular tone. Tail-cuff measurements demonstrated that awake Nkcc1(-/-) mice had significantly lower systolic blood pressure than wild-type (Nkcc1(+/+))...
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