Article
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.
American journal of physiology. Cell physiology - 1 Feb 2016
Schepelmann M, Yarova P L, Lopez-Fernandez I, Davies T S, Brennan S C, Edwards P J, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton R A, Chang W, Krssak M, Stewart A, Broadley K J, Ward D T, Price S A, Edwards D H, Kemp P J, Riccardi D
Abstract excerpt
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its role is not completely understood. In this study, we tested the hypothesis that the CaSR expressed in vascular smooth muscle cells (VSMC) is directly involved in regulation of blood pressure and blood vessel tone. Mice with targeted CaSR gene ablation from vascular smooth muscle cells (VSMC) were generated by breeding exon 7...
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