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Article

Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 May 2014

Guo Jinny J, Stoltz David A, Zhu Vivian, Volk Kenneth A, Segar Jeffrey L, McCray Paul B, Roghair Robert D

Abstract excerpt

BACKGROUND: The most common CF-causing mutations interfere with CFTR trafficking from the endoplasmic reticulum (CFTR-F508del) or prematurely terminate transcription (CFTR-null). We suspected that genotype-specific patterns of CFTR expression would have differential effects on smooth muscle cell calcium signaling and hence vascular tone. We hypothesized that compared to wild-type or CFTR-null aorta, aorta from...

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Source

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Identifiers

PMID: 24183914
DOI: 10.1016/j.jcf.2013.10.009
PMCID: PMC3972271

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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