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Article

Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction.

Cardiovascular research - 1 Sept 2007

Gilsbach Ralf, Brede Marc, Beetz Nadine, Moura Eduardo, Muthig Verena, Gerstner Carolin, Barreto Frederico, Neubauer Stefan, Vieira-Coelho Maria Augusta, Hein Lutz

Abstract excerpt

OBJECTIVE: Feedback regulation of norepinephrine release from sympathetic nerves is essential to control blood pressure, heart rate and contractility. Recent experiments in gene-targeted mice have suggested that alpha(2C)-adrenoceptors may operate in a similar feedback mechanism to control the release of epinephrine from the adrenal medulla. As heterozygous polymorphisms in the human alpha(2C)-adrenoceptor gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17597596
DOI: 10.1016/j.cardiores.2007.05.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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