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Article

Left ventricular and aortic dysfunction in cystic fibrosis mice.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Sept 2013

Sellers Zachary M, Kovacs Attila, Weinheimer Carla J, Best Philip M

Abstract excerpt

BACKGROUND: Left ventricular (LV) abnormalities have been reported in cystic fibrosis (CF); however, it remains unclear if loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes heart defects independent of lung disease. METHODS: Using gut-corrected F508del CFTR mutant mice (ΔF508), which do not develop human lung disease, we examined in vivo heart and aortic function via 2D...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23269368
DOI: 10.1016/j.jcf.2012.11.012
PMCID: PMC4170835

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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