Article
Genetic analysis of the complement pathway in C3 glomerulopathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Nov 2018
Zhao Weiwei, Ding Yin, Lu Jianping, Zhang Tao, Chen Dacheng, Zhang Haitao, Zeng Caihong, Liu Zhihong, Chen Huimei
Abstract excerpt
Background: C3 glomerulopathy often presents with a membranoproliferative glomerulonephritis (MPGN) pattern, and is principally caused by unrestricted activation of the complement alternative pathway. Genetic abnormalities of the complement system critically implicate in the pathogenesis of C3 glomerulopathy, but a systemic profile remains open, especially in Asia. Methods: In this study, we completed a...
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