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Article

Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity.

ACS chemical biology - 18 Jul 2014

Pavic Karolina, Rios Pablo, Dzeyk Kristina, Koehler Christine, Lemke Edward A, Köhn Maja

Abstract excerpt

Vaccinia H1-related (VHR) phosphatase is a dual specificity phosphatase that is required for cell-cycle progression and plays a role in cell growth of certain cancers. Therefore, it represents a potential drug target. VHR is structurally and biochemically well characterized, yet its regulatory principles are still poorly understood. Understanding its regulation is important, not only to comprehend VHR's...

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PMID: 24798147
DOI: 10.1021/cb500240n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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