Stabilization of bound polycyclic aromatic hydrocarbons by a pi-cation interaction.

Abstract excerpt

Proteins can use aromatic side-chains to stabilize bound cationic ligands through cation-pi interactions. Here, we report the first example of the reciprocal process, termed pi-cation, in which a cationic protein side-chain stabilizes a neutral aromatic ligand. Site-directed mutagenesis revealed that an arginine side-chain located in the deep binding pocket of a monoclonal antibody (4D5) is essential for binding...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigen-Antibody Complex
• Share to Benzo(a)pyrene