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Article

Promoting the activity of a receptor tyrosine phosphatase with a novel pH-responsive transmembrane agonist inhibits cancer-associated phenotypes.

Protein science : a publication of the Protein Society - 1 Sept 2023

Rizzo Sophie, Sikorski Eden, Park Soohyung, Im Wonpil, Vasquez-Montes Victor, Ladokhin Alexey S, Thévenin Damien

Abstract excerpt

Cell signaling by receptor protein tyrosine kinases (RTKs) is tightly controlled by the counterbalancing actions of receptor protein tyrosine phosphatases (RPTPs). Due to their role in attenuating the signal-initiating potency of RTKs, RPTPs have long been viewed as therapeutic targets. However, the development of activators of RPTPs has remained limited. We previously reported that the homodimerization of a...

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Identifiers

PMID: 37515426
DOI: 10.1002/pro.4742
PMCID: PMC10461461

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