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Article

Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.

Cancer immunology research - 1 May 2014

da Silva Ines Pires, Gallois Anne, Jimenez-Baranda Sonia, Khan Shaukat, Anderson Ana C, Kuchroo Vijay K, Osman Iman, Bhardwaj Nina

Abstract excerpt

The immunoregulatory protein T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates T-cell exhaustion and contributes to the suppression of immune responses in both viral infections and tumors. Tim-3 blockade reverses the exhausted phenotype of CD4+ and CD8+ T cells in several chronic diseases, including melanoma. Interestingly, natural killer (NK) cells constitutively express Tim-3;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24795354
DOI: 10.1158/2326-6066.CIR-13-0171
PMCID: PMC4046278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.PMID 24795354Read ↗

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Targeted knockdown of Tim3 by short hairpin RNAs improves the function of anti-mesothelin CAR T cellsSemantic proximity Read ↗

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Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma.Semantic proximity Read ↗

Endothelial cell-expressed Tim-3 facilitates metastasis of melanoma cells by activating the NF-κB pathwaySemantic proximity Read ↗

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Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion.Semantic proximity Read ↗

Tim-3 Promotes Early Differentiation of Tbet <sup>+</sup> Effector T Cells During Acute Viral InfectionSemantic proximity Read ↗

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