Article

Targeted knockdown of Tim3 by short hairpin RNAs improves the function of anti-mesothelin CAR T cells

2020-07-14

Abstract excerpt

<h4>Background: </h4> T-cell immunoglobulin mucin 3 (Tim3) is an immune checkpoint receptor that plays a central role in chimeric antigen receptor (CAR) T cell exhaustion within the tumor microenvironment. This study was aimed to evaluate the effects of targeted-knockdown of Tim3 on the antitumor function of anti-mesothelin (MSLN)-CAR T cells. <h4>Methods: </h4>: To knockdown Tim3 expression, three different shRNA...

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Literature Corpus work: 2bdec45f-4d47-5dd3-b3ad-de80831b31e6
DOI: 10.21203/rs.3.rs-41304/v1

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