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Article

Differential expression of Tim3 protein in colorectal cancer associated with MSI and Braf mutation.

Histology and histopathology - 1 May 2022

He Shuyan, Lin Qingfeng, Chen Jie, Ma Chenglong, Liu Zhili, Sun Yuejun, Mao Weidong, Shen Dong, Wang Jiandong

Abstract excerpt

Tim3 is a negative immune checkpoint molecule and plays a crucial part in tumor-induced immune suppression. Tim3 is a cell surface molecule expressed on T cells marking dysfunctional CD8+ cells in various kinds of cancers. Tim3 expression was mainly reported in tumor-infiltrating lymphocytes (TILs). There are few studies focusing on the expression of Tim3 in tumor cells. Immunohistochemistry was performed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34994395
DOI: 10.14670/HH-18-419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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