Article

Targeting STAT3 abrogates Tim-3 upregulation of adaptive resistance to PD-1 blockade on regulatory T cells of melanoma

2020-10-01

Abstract excerpt

<h4>Background: </h4> Programmed cell death-1 (PD-1) blockade immunotherapies have demonstrated excellent clinical benefits in multiple cancers, but < 20% of melanoma patients respond to these treatments. Thus, it is crucial to understand for getting awareness of the dynamic changes vibrant transformations in the tumor microenvironment (TME) after PD-1 blockade, in exploring novel intervention targets as a potenti...

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Literature Corpus work: 443ba0db-db86-51cd-bd38-77b8829e227a
DOI: 10.21203/rs.3.rs-83300/v1

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