Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial Metaplasia

1 May 2014

Abstract excerpt

The molecular mechanisms leading to epithelial metaplasias are poorly understood. Barrett's esophagus is a premalignant metaplastic change of the esophageal epithelium into columnar epithelium, occurring in patients suffering from gastroesophageal reflux disease. Mechanisms behind the development of the intestinal subtype, which is associated with the highest cancer risk, are unclear. In humans, it has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Digestive system and related health
Share to Esophageal and GI Pathology
Share to Metastasis and carcinoma case studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24794431
DOI: 10.1016/j.celrep.2014.03.074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial MetaplasiaPMID 24794431Read ↗

The Molecular Pathogenesis of Barrett’s Esophagus: Common Signaling Pathways in Embryogenesis Metaplasia and NeoplasiaSemantic proximity Read ↗

Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration.Semantic proximity Read ↗

Molecular mechanisms of Barrett's esophagus.Semantic proximity Read ↗

Cellular mechanisms of Barrett's esophagus development.Semantic proximity Read ↗

Acid, Bile, and CDX: the ABCs of making Barrett's metaplasiaSemantic proximity Read ↗

Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's EsophagusSemantic proximity Read ↗

CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cellsSemantic proximity Read ↗

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanismsSemantic proximity Read ↗

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotypeSemantic proximity Read ↗

Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus.Semantic proximity Read ↗

CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.Semantic proximity Read ↗

Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.