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Article

Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2004

Su Yinghao, Chen Xiaoxin, Klein Michael, Fang Ming, Wang Su, Yang Chung S, Goyal Raj K

Abstract excerpt

In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical carcinogen treatment can lead to columnar-lined esophagus (CLE) including metaplasia, dysplasia, and esophageal adenocarcinoma (EAC). This study describes the morphology and phenotypic features of CLE and EAC in the rat model and compares them with the corresponding lesions in human Barrett's esophagus (BE). Swiss roll preparations of...

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Identifiers

PMID: 15094711
DOI: 10.1038/labinvest.3700079

Genes

TFF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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