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Article

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype

9 Dec 2010

Abstract excerpt

BACKGROUND AND AIMS: Intestinal metaplasia (IM) is a gastric preneoplastic lesion that appears following Helicobacter pylori infection and confers an increased risk for development of cancer. It is induced by gastric expression of the intestine-specific transcription factor CDX2. The regulatory mechanisms involved in triggering and maintaining gastric CDX2 expression have not been fully elucidated. The Cdx2(+/-)...

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Identifiers

PMID: 21148572
DOI: 10.1136/gut.2010.222323

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