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Article

Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2006

Vallböhmer D, DeMeester S R, Peters J H, Oh D S, Kuramochi H, Shimizu D, Hagen J A, Danenberg K D, Danenberg P V, DeMeester T R, Chandrasoma P T

Abstract excerpt

The molecular pathogenesis of Barrett's esophagus is poorly understood. Evidence suggests that at a phenotypic level, the metaplastic process begins with the transformation of squamous epithelium in the distal esophagus to cardiac mucosa, which subsequently becomes intestinalized. The homeobox gene Cdx-2 has been shown to be an important transcriptional regulator of embryonic differentiation and maintenance of...

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Identifiers

PMID: 16866857
DOI: 10.1111/j.1442-2050.2006.00586.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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