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CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells

27 Apr 2022

Abstract excerpt

Intestinal metaplasia is related to gastric carcinogenesis. Previous studies have suggested the important role of CDX2 in intestinal metaplasia, and several reports have shown that the overexpression of CDX2 in mouse gastric mucosa caused intestinal metaplasia. However, no study has examined the induction of intestinal metaplasia using human gastric mucosa. In the present study, to produce an intestinal...

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PMID: 35602937
DOI: 10.1016/j.isci.2022.104314

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