Article
IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia.
Journal of cancer research and clinical oncology - 1 Sept 2014
Wróbel Tomasz, Gębura Katarzyna, Wysoczańska Barbara, Jaźwiec Bożena, Dobrzyńska Olga, Mazur Grzegorz, Kuliczkowski Kazimierz, Bogunia-Kubik Katarzyna
Abstract excerpt
PURPOSE: Recent studies have suggested that Th17 cells may play a role in the pathogenesis of acute myeloid leukemia (AML). This subset of CD4+ cells is characterized by interleukin (IL)-17A and IL-17F production, which share strong homology, and surface expression of the IL-23 receptor (IL-23R). The present study aimed to determine the association between the polymorphic features located within the IL-17A,...
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